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June 9, 2026Clinical Oral InvestigationsOpen Access

Anhydrous stannous fluoride toothpaste in dentin hypersensitivity: clinician-assessed and patient-reported outcomes from two controlled trials

Jianhong Qiu Jonathan E. Creeth Abeera Mohammad Kimberly R Milleman John Gallob Jeffery Milleman Monica Pradhan J Qaqish

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Key Points

This research aims to evaluate the effectiveness of anhydrous stannous fluoride toothpaste in reducing dentin hypersensitivity compared to standard fluoride toothpaste.
Two parallel independent studies with randomization between the test (SnF₂) and reference (standard fluoride) toothpastes.
Examiner-blind assessments for dentin hypersensitivity using evaporative and tactile stimuli.
Patient-reported outcomes measured with Labelled Magnitude Scales and the Dentin Hypersensitivity Experience Questionnaire at baseline, Day 28, and Day 56.
The Test group showed a statistically significant reduction in Schiff sensitivity scores by Day 28 and 56 (p < 0.05).
An increase in tactile threshold was observed in the Test group compared to Reference treatments (p < 0.05).
Significantly greater improvements in DHEQ scores for the Test group versus Reference at Day 56.

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Implication

Demonstrates significant reduction of dentin hypersensitivity in adults using stannous fluoride toothpaste, suggesting it as an effective treatment.

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Cite This Study

Qiu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52d980c8f91e7f39eca3 https://doi.org/10.1007/s00784-026-06942-4

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial2024 · 11 citations
2Randomized Controlled Trials Assessing Exposure Frequency Effects of Stannous Fluoride on Gingivitis2024
3Comparative Efficacy of Two Occluding Toothpastes: An 8 Weeks Randomised Control TrialRCT · 2026
4Comparative investigations of the desensitising efficacy of a new dentifriceCohort Study · 2001 · 77 citations
5Comparative efficacy of novel bioactive glass versus sodium fluoride toothpaste for dentin hypersensitivity2025 · 2 citations