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June 11, 2026Coronaviruses

Comparative Utility of Targeted Amplicon Sequencing vs. Whole Genome Approaches in SARS-CoV-2 Molecular Surveillance: A ComprehensiveReview

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Authors

MSMehdi ShabaniANAhmad NejatiKSKaveh Sadeghi

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Overview

Comprehensive review compares sequencing methods for identifying SARS-CoV-2 mutations, indicating their importance in controlling the pandemic.

Key Points

  • This review aims to assess the effectiveness of targeted amplicon sequencing versus whole genome sequencing in monitoring SARS-CoV-2 mutations.
  • Performed a literature search across PubMed, Google Scholar, and Scopus for studies on SARS-CoV-2 sequencing.
  • Compared mutations in the S gene with other viral genes to evaluate roles in transmission and pathogenicity.
  • Analyzed cost, turnaround time, analytical resolution, and surveillance suitability for whole genome and S gene sequencing.
  • Targeted amplicon sequencing can effectively monitor mutations in the S gene, aiding in tracking transmissibility.
  • Whole genome sequencing reveals mutations influencing pathogenicity that are distributed across various genomic regions.
  • Whole genome sequencing is generally more expensive but provides comprehensive insights into viral evolutionary trends.

Cite This Study

Shabani et al. (2026) studied this question.

synapsesocial.com/papers/6a2a533380c8f91e7f39ed3chttps://doi.org/10.2174/0126667975445559260523172327
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