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April 13, 2026Epidemiology and InfectionOpen Access

Local genomic epidemiology investigations of SARS-CoV-2 during the early pandemic response: A global systematic review

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Authors

LMLindsay MortonBFBrett M. ForsheyKKKatharina E. Klinkhammer

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Overview

Systematic review reveals genomic approaches enhance outbreak investigations globally, indicating their importance for public health.

Key Points

  • The review aimed to explore how whole-genome sequencing contributed to local outbreak investigations of SARS-CoV-2 during the early pandemic.
  • Conducted a systematic review of studies from March 2020 to March 2021.
  • Identified 32 studies utilizing genomic and epidemiological data through database searches.
  • Analyzed study contexts focusing on healthcare settings and geographic diversity.
  • Confirmed transmission links, detected multiple introductions, and identified asymptomatic cases using genomic data.
  • Dominated by studies in high-income countries, with limited representation from low-and middle-income countries.
  • Highlighted the importance of open-access genomic databases and standardized protocols.

Cite This Study

Morton et al. (2026) studied this question.

synapsesocial.com/papers/69dc87ea3afacbeac03e9fd4https://doi.org/10.1017/s0950268826101381
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