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Experimental model reveals how glycosides are absorbed in cells, blocking mechanisms suggest avenues for further research.
prediction model also supported these observations. The absorption of glycosides, especially diglycosides but not the aglycones, was significantly blocked by SGLT1 and GLUT2 inhibitors (phloridzin and phloretin) and further validated in SGLT1 knockdown Caco-2 BBe1 cells.
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Zhang et al. (2020) studied this question.
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