The Prevalence of Endothelial Dysfunction in Patients With and Without Coronary Artery Disease
Key result
Chronic and acute coronary artery disease were associated with significantly lower hyperemia ratios (1.81 and 1.74, respectively) compared to patients without CAD (2.02; P≤0.001).
Why the study?
Does the presence of coronary artery disease and cardiovascular risk factors correlate with endothelial dysfunction in patients referred for coronary angiography?
Study Design
Type
Cross-Sectional (n=341)
Structured PICO
Does the presence of coronary artery disease and cardiovascular risk factors correlate with endothelial dysfunction in patients referred for coronary angiography?
P
Population
341 consecutive patients referred for coronary angiography evaluated for endothelial dysfunction.
E
Exposure
Presence of coronary artery disease (chronic or acute) and cardiovascular risk factors
C
Comparator
Absence of coronary artery disease
O
Outcome
Endothelial dysfunction measured by hyperemia ratio using pulse wave analysis with a finger plethysmographsurrogate
Main Result
Absolute Event Rate: 1.81% vs 2.02%
p-value: p=0.001
Endothelial dysfunction is highly prevalent in patients with chest pain, correlating strongly with the presence of CAD and the number of cardiovascular risk factors, even in those without angiographic CAD.
Authors
Discussion
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Implication
Endothelial dysfunction links to CAD in angiography referrals; confirms risk factor correlation but leaves open prognostic or therapeutic implications.
Cite This Study
Toggweiler et al. (2010) conducted a cross-sectional in Coronary Artery Disease (n=341). Coronary artery disease vs. No coronary artery disease was evaluated on Hyperemia ratio (p=0.001). Chronic and acute coronary artery disease were associated with significantly lower hyperemia ratios (1.81 and 1.74, respectively) compared to patients without CAD (2.02; P≤0.001).