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OBJECTIVES: The world's population is getting older and the number of people suffering from arthritis is a major problem according to World Health Organization's data. In this respect, the need for more efficient treatment for arthritis becomes an urgent issue. In this research, nanoparticle bearing in situ gelling hydrogel formulation was developed for prolonged local delivery of diclofenac sodium (DS). MATERIALS AND METHODS: gelling hydrogel formulations were optimized to increase the time interval between each dose application for enhanced patience compliance. RESULTS: hydrogel prepared by using poloxomer 407 and chitosan. CONCLUSION: Local administration of DS with this novel delivery system could be considered of having potential to minimize side effects associated with decreased amount of drug in dosage form compared to conventional oral dose.
Küçüktürkmen et al. (Mon,) studied this question.