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This report aims to explore the potential for seizures following abrupt clozapine discontinuation.

June 12, 2026Psychopharmacology BulletinOpen Access

Can Abrupt Discontinuation of Clozapine Cause Seizures?

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Case report demonstrates seizures from abrupt clozapine withdrawal in a patient with schizophrenia, highlighting clinical implications.

This report aims to explore the potential for seizures following abrupt clozapine discontinuation.
Case report of a 45-year-old man diagnosed with paranoid schizophrenia who abruptly stopped clozapine after 20 years.
Monitoring and assessment of seizures following discontinuation, with no alternative medical causes identified.
Discussion on the implications of abrupt withdrawal and recommendations for gradual tapering.
Two weeks after stopping clozapine, the patient experienced two generalized tonic-clonic seizures.
No medical cause other than clozapine discontinuation was identified, supporting the link between withdrawal and seizures.
Emphasizes the necessity of careful management during clozapine discontinuation, particularly recommending a gradual taper.

Pereira et al. (2026) studied this question.

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