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January 1, 2026Japanese Journal of Physiological Psychology and PsychophysiologyOpen Access

Chronic activation of NMDA-type glutamate receptors in the lateral amygdala after consolidation of associated fear-memory accelerates extinction but not forgetting

Junya TACHIKAWA Toshimichi Hata

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Key Points

This research examines how chronic activation of NMDA-type glutamate receptors affects forgetting and extinction of fear memories after their consolidation.
24 hours post-fear conditioning, NMDA receptor agonist was continuously administered in lateral amygdala using an osmotic pump.
Evaluated fear memory retention using conditioned suppression after 14 days of conditioning.
Focused on the impact of NMDA on extinction versus forgetting of fear memories.
Chronic NMDA administration did not affect forgetting of fears.
It significantly accelerated the extinction of fear memories derived from conditioning.

Implication

Investigates NMDA's effects on memory extinction in rats, suggesting therapeutic potential for fear treatment.

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Cite This Study

TACHIKAWA et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba18c8101cf8926f00f32 https://doi.org/10.5674/jjppp.2601oa

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Memory reconsolidation impairment by amyloid beta (1–42) and its prevention by non-competitive antagonists of NMDA receptors2025 · 1 citations
2Modulating N-Methyl D-Aspartate Receptors to Enhance Learning of Safety Memories in a Rodent Model of Exposure Therapy2024
3Role of the NMDA Receptor and Nitric Oxide in Memory Reconsolidation of Cocaine‐Induced Conditioned Place Preference in MiceOriginal Research · 2008 · 61 citations
4Intense training prevents the amnestic effect of inactivation of dorsomedial striatum and induces high resistance to extinction2024 · 3 citations
5Attenuation of Emotional and Nonemotional Memories after their Reactivation: Role of β Adrenergic ReceptorsOriginal Research · 1999 · 464 citations

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