Summary of the Latest Reports on Rosacea Treatment With Topical Preparations Containing Minocycline

Introduction and Objective: Rosacea is a chronic inflammatory disease of the facial skin. The main symptoms include erythema, papules, and pustules. It affects approximately 5.5% of the adult population and occurs more frequently in women. Its aetiology is complex. Genetic, immunological, and environmental factors are involved in the pathogenesis. Treatment options include topical and systemic antibiotic therapy and the elimination of aggravating factors. Among drugs used with a good therapeutic effect, minocycline can be mentioned. This study aims to review the current scientific literature and summarise the latest findings on the treatment of rosacea with topical minocycline formulations. Review Methods: The literature review was conducted based on scientific publications from 2017 to 2025. The PubMed and Google Scholar databases were used for the search. English-language publications meeting the thematic and substantive criteria were analysed. Brief description of the state of knowledge: Tetracycline antibiotics, including minocycline, are the mainstay of rosacea treatment. Minocycline is highly lipophilic and has the highest efficacy among tetracyclines. Clinical studies confirm its effectiveness in both oral and topical forms. Modern topical formulations enable effective therapy. Summary: Rosacea is a chronic inflammatory facial skin disease that significantly reduces patients’ quality of life. Minocycline, due to its anti-inflammatory and antibacterial properties, is effective in treating moderate to severe forms of the disease. Topical formulations, particularly the 1,5% concentration foam, demonstrate high efficacy and good tolerability.