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June 12, 2026动物学研究Open Access

β-Glucan training reprograms long chain fatty acid peroxidation for reactive oxygen species production in neutrophils

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Authors

CSCui ShuHZHongxia ZhouRHRen Hui

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Overview

Randomized trial shows enhanced ROS production in neutrophils, indicating potential targets for improving immunity.

Key Points

  • This study aims to investigate how β-glucan training affects neutrophil metabolism and reactive oxygen species production.
  • Established a β-glucan training model in turbot
  • Analyzed ROS production and ACOX1 expression in neutrophils
  • Extended findings to a murine model to assess conserved effects
  • ACOX1 was significantly upregulated in trained neutrophils, enhancing ROS production
  • Pharmacological inhibition of the ACOX1-ROS axis reduced myeloperoxidase activity and NETs formation
  • In murine models, β-glucan training maintained a similar increase in ACOX1-dependent ROS generation

Cite This Study

Shu et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba1ca8101cf8926f0108bhttps://doi.org/10.24272/j.issn.2095-8137.2026.182
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