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This study examines how childhood maltreatment affects brain structure and later functioning in young adults.

Childhood maltreatment is linked to transdiagnostic age- and sex-specific cortical thinning and reduced amygdalar volume in young adults

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Randomized trial finds links between childhood maltreatment, brain changes, and functioning in young adults, suggesting unique assessment needs.

This study examines how childhood maltreatment affects brain structure and later functioning in young adults.
Transdiagnostic sample of 251 individuals (mean age 24.9, 51.8% male) assessed for childhood maltreatment and brain structure.
Utilized multivariate sparse partial least squares algorithm to analyze associations between grey-matter volume and the Childhood Trauma Questionnaire.
Performed support-vector machine analyses to identify trauma-related loadings in females.
Identified associations between physical abuse and cortical thinning (ρ =0.424, p =.007; R² = 18%).
Emotional abuse predicted poorer functioning in females at 1-year (β =-0.45, p <.001) and 2-year (β =-0.48, p <.001) follow-ups.
SVM analyses classified females with higher trauma loadings using clinical features, with a balanced accuracy of 69.2% (p =.038).

Huth et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial finds links between childhood maltreatment, brain changes, and functioning in young adults, suggesting unique assessment needs.

This study examines how childhood maltreatment affects brain structure and later functioning in young adults.
Transdiagnostic sample of 251 individuals (mean age 24.9, 51.8% male) assessed for childhood maltreatment and brain structure.
Utilized multivariate sparse partial least squares algorithm to analyze associations between grey-matter volume and the Childhood Trauma Questionnaire.
Performed support-vector machine analyses to identify trauma-related loadings in females.
Identified associations between physical abuse and cortical thinning (ρ =0.424, p =.007; R² = 18%).
Emotional abuse predicted poorer functioning in females at 1-year (β =-0.45, p <.001) and 2-year (β =-0.48, p <.001) follow-ups.
SVM analyses classified females with higher trauma loadings using clinical features, with a balanced accuracy of 69.2% (p =.038).

Huth et al. (2026) studied this question.

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