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June 12, 2026Scientific ReportsOpen Access

Single-cell and experimental analyses identify mitochondria-related genes Hmgcs2, Nudt5, and Cpt1c in painful diabetic peripheral neuropathy

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Authors

JCJiaqi CaoGuiyang Medical UniversityZZZhongjie ZhangGuiyang Medical UniversityY(Yu Chen (29959)Fujian Normal University

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Implication

Randomized trial identifies mitochondria-related genes leading to therapeutic options in painful diabetic peripheral neuropathy, suggesting new treatment avenues.

Key Points

  • The study aimed to identify mitochondria-related genes involved in the pathogenesis of painful diabetic peripheral neuropathy and explore their biological significance.
  • Conducted single-cell transcriptomic analysis to identify key mitochondria-related genes across two datasets.
  • Validated findings in rat models of painful diabetic peripheral neuropathy.
  • Performed molecular docking and dynamics simulations to identify potential therapeutic compounds.
  • Identified key genes Hmgcs2, Nudt5, and Cpt1c that showed distinct expression patterns in fibroblasts and macrophages.
  • Hmgcs2 and Nudt5 were downregulated in fibroblasts, while Cpt1c was upregulated; the opposite pattern was observed in macrophages.
  • Molecular docking revealed chlorothiazide and hydrochlorothiazide as stable binders to HMGCS2, implying potential therapeutic applications.

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba1ca8101cf8926f01182https://doi.org/10.1038/s41598-026-54769-6
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