Synthesis and Biological Evaluation of a PET Probe: 4-Borono-2-[ ¹⁸ F]fluoro- l -phenylalanine ([ ¹⁸ F]FBPA) via an Iodonium Ylide Method for BNCT

Weihao Li; ZiLong Hu; Jian Sun; Guohua Ding; Dongmin Wang; Y Zhang; S K Wang; Mingyou Hu

doi:10.1021/acs.joc.6c00536

June 9, 2026The Journal of Organic Chemistry

Synthesis and Biological Evaluation of a PET Probe: 4-Borono-2-[ ¹⁸ F]fluoro- l -phenylalanine ([ ¹⁸ F]FBPA) via an Iodonium Ylide Method for BNCT

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Key Points

This research aims to develop and evaluate a new PET probe for use in boron neutron capture therapy.
Synthesis of 4-borono-2-[18F]fluoro-l-phenylalanine using an iodonium ylide method.
Biological evaluation of the probe in tumor cell models.
The synthesized probe showed significant uptake in tumor cells, indicating its potential effectiveness.
Less damage to surrounding healthy cells was observed, suggesting a targeted treatment approach.

Implication

Evaluates the effectiveness of a novel PET probe in targeting tumor cells, suggesting potential for improved cancer treatments.

Abstract

Boron neutron capture therapy (BNCT) is a promising radiotherapeutic strategy for cancer treatment that selectively eradicates tumor cells while minimizing damage to surrounding healthy cells. 4-Borono-2-[

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba20e8101cf8926f0124a https://doi.org/10.1021/acs.joc.6c00536

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Synthesis and Biological Evaluation of a PET Probe: 4-Borono-2-[ ¹⁸ F]fluoro- l -phenylalanine ([ ¹⁸ F]FBPA) via an Iodonium Ylide Method for BNCT

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis and Biological Evaluation of a PET Probe: 4-Borono-2-[ ¹⁸ F]fluoro- l -phenylalanine ([ ¹⁸ F]FBPA) via an Iodonium Ylide Method for BNCT

Key Points

Implication

Abstract

Discussion

Cite This Study

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