We report the case of a 27-year-old male who developed elevated liver enzymes during treatment with low-dose mirtazapine for insomnia. Liver function normalized after discontinuation of the drug, supporting a probable drug-induced liver injury (DILI). This case highlights the need for hepatic monitoring during mirtazapine therapy, even at low doses and in asymptomatic patients.
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Sellami et al. (2026) studied this question.
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