Why the study?
Does mirtazapine affect plasma lipid profiles and body weight in healthy subjects?
Population
50 healthy subjects (30 women and 20 men)
Comparison
Mirtazapine 15 mg daily initially, increased to… vs Placebo for a 4-week period
Design
RCT, randomized, double-blind
Follow-up
4 weeks
Authors
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Clinicians should monitor lipids and weight with mirtazapine initiation; extends RCT evidence of early metabolic effects to healthy subjects.
Does mirtazapine affect plasma lipid profiles and body weight in healthy subjects?
Mirtazapine treatment in healthy subjects is associated with increased total cholesterol and body weight, but does not adversely affect LDL levels or the TC/HDL ratio.
Nicholas et al. (2003) studied this question.
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