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June 10, 2026Pediatric Critical Care Medicine

Inflammatory Markers for Nosocomial Infections in Pediatric Extracorporeal Membrane Oxygenation: Single-Center Retrospective Cohort, 2017–2022

Ethan Gillett Esma Birişçi J. Blake Frazier Michael H. Stroud Matthew P. Malone

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Key Points

This evaluation aims to assess the effectiveness of inflammatory markers in diagnosing nosocomial infections in pediatric ECMO patients.
Single-center retrospective cohort analysis of pediatric patients on ECMO from 2017 to 2022
Evaluated diagnostic performance of WBC count, CRP, and procalcitonin
Analyzed data from 154 ECMO runs involving 151 patients.
New infections identified in 63 of 154 ECMO runs (41%)
CRP had AUC of 0.66 (95% CI, 0.60-0.72) and procalcitonin AUC of 0.62 (95% CI, 0.53-0.72) for diagnostic accuracy
Normal procalcitonin (<1.77 ng/mL) had a 95% negative predictive value, CRP (<36.5 mg/L) had a 97% NPV.

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Implication

Retrospective cohort evaluates diagnostic markers for nosocomial infections in pediatric ECMO patients, suggesting implications for antibiotic use.

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Cite This Study

Gillett et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2448101cf8926f014da https://doi.org/10.1097/pcc.0000000000003979

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