Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 12, 2026BiomedicinesOpen Access

BDNF-Hyaluronic Acid Hydrogel Promotes Neuronal Differentiation of Neural Stem Cells in Aβ-Induced Injury and 5×FAD Mice

View Full Paper
Ask AI
Bookmark
Share

Authors

KCKangzhen ChenHSHehang ShiYBYuanyuan Bai

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates BDNF-HA gel's effects on neurogenesis and memory in Alzheimer's disease models, suggesting potential therapeutic benefits.

Key Points

  • This study aims to evaluate the effects of BDNF-HA gel on neuronal differentiation and cognitive functions in the context of Alzheimer's disease.
  • Established an in vitro model of Aβ1–42 oligomer-damaged neural stem cells (NSCs) for testing BDNF-HA gel.
  • Administered BDNF-HA gel intracerebroventricularly to 5×FAD mice and assessed outcomes using BrdU labeling and behavioral tests.
  • Used immunofluorescence and viral tracing to evaluate NSC proliferation, differentiation, and effects on memory circuits.
  • In vitro, BDNF-HA gel reduced NSC apoptosis (p<0.05), enhanced proliferation and differentiation into neuroblasts and newborn neurons.
  • In vivo, BDNF-HA gel improved NSC proliferation in SVZ (HR=1.8, 95% CI 1.1-2.5, p=0.03) without reducing Aβ plaques.
  • Significant improvements observed in object recognition and spatial memory tasks (p<0.01).

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2448101cf8926f01586https://doi.org/10.3390/biomedicines14061316
View Full Paper
Ask AI
Bookmark
Share