What question did this study set out to answer?

The study aims to evaluate the immunomodulatory effects of mesenchymal stem cells (MSCs) on splenic macrophage responses during Plasmodium berghei ANKA infection.

June 12, 2026International Reviews of Immunology

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection

View Full Paper

Ask AI

Bookmark

Authors

AGAarti GuptaNational Institute of Malaria Research RTReva Sharan ThakurNational Institute of Malaria Research RORajesh Kumar OjhaNational Institute of Malaria Research

Discussion

Member takes

Implication

Randomized trial investigates MSC effects on immune modulation in cerebral malaria, suggesting therapeutic potential.

Key Points

The study aims to evaluate the immunomodulatory effects of mesenchymal stem cells (MSCs) on splenic macrophage responses during Plasmodium berghei ANKA infection.
C57BL/6 mice infected with Plasmodium berghei ANKA received MSCs intravascularly on the infection day.
BB integrity was measured with Evans blue, and brain pathology was evaluated histologically.
Macrophage polarization was assessed using flow cytometry for M1 and M2 markers, and gene expression was analyzed via quantitative real-time PCR.
MSCs reduced parasitemia and improved survival rates, preserving blood-brain barrier integrity (P<0.01).
Flow cytometry identified decreased M1 marker expression with increased M2 markers, promoting a balanced macrophage response.
Gene expression analysis indicated downregulation of iNOS-2 and upregulation of Arginase-1, EGR-2, GPR-18, FPR-1, and PTGES-2.

Cite This Study

Gupta et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2708101cf8926f0166c https://doi.org/10.1080/08830185.2026.2683964

View Full Paper

Ask AI

Bookmark

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider