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This research investigates the relationship between bilirubin, albumin, and the ALBI index with gastric cancer risk, focusing on smoking status.

June 12, 2026BMC GastroenterologyOpen Access

Associations of bilirubin, albumin, and the ALBI index with gastric cancer risk: a smoking-stratified prospective cohort study in men

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Prospective cohort study explores antioxidant biomarkers' impact on gastric cancer risk by smoking status.

This research investigates the relationship between bilirubin, albumin, and the ALBI index with gastric cancer risk, focusing on smoking status.
Analyzed data from the KCPS-II cohort with 83,371 men participants who were cancer-free at baseline.
Identified 1,162 cases of gastric cancer during a mean follow-up of 13.5 years.
Used Cox proportional hazards regression models to calculate hazard ratios and confidence intervals.
A 1 SD increase in bilirubin was inversely associated with gastric cancer in ever-smokers (HR: 0.80, 95% CI: 0.65–0.98).
Albumin showed the strongest inverse association for ever-smokers (HR: 0.59, 95% CI: 0.45–0.77).
The ALBI index was inversely associated with gastric cancer among ever-smokers (HR: 0.74, 95% CI: 0.56–0.99).

Shin et al. (2026) studied this question.

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