What question did this study set out to answer?

This research aims to synthesize benzimidazole Schiff bases and assess their dual inhibitory activity against acetylcholinesterase and butyrylcholinesterase.

June 12, 2026Future Medicinal Chemistry

Benzimidazole derived hydrazone Schiff bases as potent cholinesterase inhibitors: synthesis, in vitro and in silico approaches

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Authors

ASAbdul ShakoorMehran University of Engineering and Technology AEAhmed A. ElhenawyAl-Azhar University AAAftab AlamRawalpindi Medical University

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Implication

Randomized trial evaluates the inhibition of cholinesterase in synthetic benzimidazole derivatives, implying their potential in treating Alzheimer's disease.

Key Points

This research aims to synthesize benzimidazole Schiff bases and assess their dual inhibitory activity against acetylcholinesterase and butyrylcholinesterase.
Synthesis of ten benzimidazole Schiff bases characterized by spectroscopic techniques.
Assessment of in vitro AChE and BuChE inhibitory activities of the synthesized compounds.
Density functional theory and molecular docking studies to analyze electronic properties and ligand interactions.
Compounds 2c, 2f, 2h, 2a, and 2b showed potent inhibition against AChE and BuChE comparable to galantamine.
DFT analysis indicated that higher electrophilicity and lower hardness enhance inhibitory activity.
Docking studies confirmed favorable binding interactions with the active site of cholinesterases.

Cite This Study

Shakoor et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba2c18101cf8926f019d9 https://doi.org/10.1080/17568919.2026.2684691

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Implication

Randomized trial evaluates the inhibition of cholinesterase in synthetic benzimidazole derivatives, implying their potential in treating Alzheimer's disease.

Benzimidazole derived hydrazone Schiff bases as potent cholinesterase inhibitors: synthesis, in vitro and in silico approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

Benzimidazole derived hydrazone Schiff bases as potent cholinesterase inhibitors: synthesis, in vitro and in silico approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

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