Ustekinumab-induced Focal Segmental Glomerulosclerosis in a Patient with Crohn’s Disease

Introduction: We present the case of a 22-year-old woman with Crohn’s disease who developed nephrotic syndrome following Ustekinumab therapy. This is the first case in the literature. Main Symptoms: The patient started to have massive bilateral lower limb swellings with proteinuria. Renal biopsy revealed focal segmental glomerulosclerosis. Ustekinumab was held which led to complete resolution of the symptoms and proteinuria. Conclusion: This case highlights the potential nephrotoxic effects of ustekinumab and underscores the importance of close monitoring for renal complications in patients with inflammatory bowel disease receiving biologic therapy.