International Validation of Temperature-Trajectory Sepsis Subphenotypes With Longitudinal Immune and Coagulation Patterns and Its Implications for Immunoglobulin Therapy

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Key Points

This study aims to validate a temperature-trajectory model of sepsis and explore the associated immune and coagulation dynamics.
Validated a temperature-trajectory model of sepsis in a non-U.S. cohort (China).
Characterized longitudinal immune and coagulation dynamics across sepsis subphenotypes.
Compared clinical characteristics and assessed interaction between subphenotypes and immunoglobulin therapy on mortality.
Identified four subphenotypes: hyperthermic slow resolvers, hyperthermic fast resolvers, normothermic, and hypothermic (HT).
HT subphenotype had the highest mortality rate (25%).
Immunoglobulin therapy showed benefits in the HT subphenotype (hazard ratio 0.47; p=0.03).

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Validates temperature-trajectory sepsis subphenotypes in ICU patients, indicating implications for immunoglobulin therapy.

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Wang et al. (2026) studied this question.

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