Retrospective cohort study shows arterial blood gas parameters predict ICU admission risk in acute carbon monoxide poisoning, indicating the importance of careful monitoring.
This single-centre retrospective cohort study demonstrates that arterial blood gas (ABG) parameters independently stratify ICU admission risk in acute carbon monoxide poisoning (ACOP) beyond carboxyhemoglobin (COHb). Among 124 ACOP patients, the acidosis group (pH<7.35) had a higher ICU admission rate [44.8%, 95% Confidence Interval (CI): 26.8%∼63.7%] than the normal p H (17.7%, 95%CI: 10.1%∼27.5%) and alkalemia groups (12.5%, 95%CI: 1.6%∼38.3%, P <0.001), with a median COHb of 33.1%. The acidosis group presented severe metabolic disturbance (median lactate 7.60 mmol/L, GCS 7). Spearman analysis showed arterial lactate was more strongly associated with disease severity markers than COHb. Multivariate logistic regression confirmed GCS score, COHb, arterial lactate, and HCO3 as independent predictors for ICU admission.
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Ke et al. (2026) studied this question.
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