Clinical gut attractor: the role of microbiota and chaotic systems in the evolution of biological functions

From the simplest organisms to cnidarians, mammals, and humans, animal physiology has been governed by the laws of chaos. Evolution occurs through the struggle of opposites. In cnidarians, this dynamic is represented by the interaction between the gut microbiota and immune peptides. A unique and highly dynamic community has emerged, consisting of gut microbiota, immune cells, and the epithelial cells of Hydra’s "gut." Drawing an analogy from ancient Roman history, we refer to this community as the "triumvirate." This triumvirate plays a central role in regulating all cellular processes and functions in cnidarians. Changes in the composition of the microbiota can alter the functional state of the host organism. In response, the system synthesizes the necessary immune peptides to restore equilibrium between the microbiota, immune compounds, and epithelial cells. This regulatory process follows a pendulum-like pattern characteristic of chaotic systems. As a result, the entire triumvirate, along with all cells of the host organism, forms what we term the "clinical gut attractor." The clinical gut attractor is the primary regulatory system in cnidarians, governing digestion, neural activity, secretion, vision, and vascular function. As mammals continue to evolve, their secretory, respiratory, and sensory systems interact with the external environment, developing distinct microbiota. This leads to the emergence of new clinical attractors, which coordinate the functions of the entire human body. This theory presents a fresh perspective on the origins of human diseases, offering new avenues for therapeutic approaches.