Titanium Implant Abutments With Polydopamine‐Mesoporous Cerium Dioxide Coatings for Enhanced Antibacterial, Anti‐Inflammatory, and Soft Tissue Integration Properties

The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment. Therefore, endowing titanium abutment with ideal antibacterial, anti‐inflammatory, and soft tissue integration properties is crucial to improving the clinical success rate of implant therapy. This study reports a mussel‐inspired composite coating composed of polydopamine (PDA) and mesoporous cerium dioxide (CeO 2 ) particles, which innovatively achieves a “dual‐stage active regulation” function. In the early stage after implant placement, the coating exhibits reactive oxygen species (ROS) scavenging activity, achieving a ROS scavenging rate exceeding 80%. It exerts inherent antibacterial effects by directly contacting bacterial membranes and disrupting biological functions, thereby preventing peri‐implantitis at the source and promoting early soft tissue integration. When an infection occurs, near‐infrared (NIR) irradiation triggers a photothermal–chemical synergistic antibacterial effect between PDA and CeO 2 , achieving 100% bactericidal efficacy against Escherichia coli and Staphylococcus aureus , thereby reversing the infection process. Furthermore, the study elucidates that the underlying anti‐inflammatory mechanism of the PDA–CeO 2 coating involves downregulating the tumor necrosis factor (TNF) signaling pathway in macrophages, inhibiting M1 macrophage polarization, and reshaping a regenerative immune microenvironment. This research provides an intelligent abutment modification strategy combining “early active prevention” and “on‐demand treatment after infection,” offering an innovative solution to enhance the long‐term success rate of dental implants.