Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 12, 2026Open Access

Investigating Placental Gene Expression Changes Associated with Preeclampsia in the Environment, Perinatal Outcomes, and Child Health (EPOCH) Cohort

View Full Paper
Ask AI
Bookmark
Share

Authors

CWChristopher WoodMotorola (United States)

Discussion

Loading...

Member takes

Overview

Targeted gene expression analysis reveals dysregulated pathways in preeclampsia, highlighting molecular insights.

Key Points

  • The aim is to understand the molecular mechanisms underlying preeclampsia through placental gene expression analysis.
  • Conducted targeted gene expression analysis using placental tissue from the EPOCH cohort.
  • Total RNA extracted and analyzed with high-throughput PCR via the Fluidigm platform.
  • Adjusted for relevant covariates and batch effects in the analysis.
  • No significant differences in gene expression between preeclamptic and normotensive placentas were observed.
  • Key genes related to angiogenesis, immune response, and cellular migration were dysregulated in preeclamptic placentas.
  • Findings highlight the variability of gene expression studies and the need for further research.

Cite This Study

Christopher Wood (2026) studied this question.

synapsesocial.com/papers/6a2ba44e8101cf8926f02b98https://doi.org/10.17615/ev5c-by77
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiomics integrative bioinformatics analysis of gene expression characteristics and molecular mechanisms in preeclampsia placental tissue2026
  2. 2Proteomic Analysis Reveals Differential Protein Expression in Placental Tissues of Early-Onset Preeclampsia Patients2024
  3. 3Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications2025
  4. 4Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers2024 · 12 citations
  5. 5Placental Origins of Preeclampsia: Insights from Multi-Omic Studies2024 · 25 citations