Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 12, 2026International Journal of Molecular SciencesOpen Access

Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model

View Full Paper
Ask AI
Bookmark
Share

Authors

AOAbosede Temitope OlajideSASasithon AunsornSKSamuel Abiodun Kehinde

Discussion

Loading...

Member takes

Overview

Randomized trial examines antioxidant and neuroprotective roles of Bacopa monnieri in cognitive impairment, suggesting potential benefits.

Key Points

  • This study investigates the phytochemical profile, antioxidant activity, and neuroprotective effects of Bacopa monnieri extract in a dementia model.
  • Bacopa monnieri extract was prepared using ethanol for extraction.
  • Antioxidant activity was assessed using in vitro tests including DPPH, ABTS, and FRAP.
  • Rats were pre-treated with extract before being administered lipopolysaccharide to induce cognitive impairment.
  • BME showed significant antioxidant activity with effective radical scavenging properties.
  • In the LPS-induced model, pre-treatment with BME at 70 mg/kg did not significantly improve cognitive scores compared to controls.
  • BME reduced neuroinflammatory markers IL-1β, TNF-α, and others, indicating potential protective mechanisms.

Cite This Study

Olajide et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4a18101cf8926f02f3chttps://doi.org/10.3390/ijms27125229
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease: Protocol for an Exploratory Double-Blind, Randomized, Placebo-Controlled Trial2026 · 5 citations
  2. 2Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus2014 · 69 citations
  3. 3<i>Bacopa monnieri</i> protects neuronal cell line and <i>Caenorhabditis elegans</i> models of Alzheimer’s disease through sigma-1 receptor antagonist sensitive and antioxidant pathways2022 · 8 citations
  4. 4PHYTOCHEMICAL ANALYSIS AND IN VITRO BIOLOGICAL CHARACTERIZATION OF AQUEOUS AND METHANOLIC EXTRACT OF BACOPA MONNIERI2016 · 12 citations
  5. 5Working Memory in the Prefrontal Cortex2017 · 326 citations