Discontinuation of medications for alcohol use disorder in the United States: Patient, prescriber and medication predictors

Alisa B. Busch; Dominic Hodgkin; Alene Kennedy‐Hendricks; Grant A. Ritter; Lori Uscher‐Pines; Constance M. Horgan; Haiden A. Huskamp

doi:10.1111/add.70498

June 9, 2026Addiction

Discontinuation of medications for alcohol use disorder in the United States: Patient, prescriber and medication predictors

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Key Points

This study aims to identify factors associated with the discontinuation of medications for alcohol use disorder (MAUD) in the United States.
Observed a cohort of 51,915 individuals with alcohol use disorder utilizing MAUD from 2017 to 2024.
Employed an accelerated failure time log logistic survival model to analyze time to MAUD discontinuation, adjusting for various characteristics.
Defined discontinuation as a gap in pharmacy fills of more than 7 days.
Median time to MAUD discontinuation was 30 days, with significant variation among medications (e.g., 30 days for acamprosate/naltrexone, 60 days for topiramate).
Older age and being prescribed topiramate were associated with longer MAUD duration, while lower household income correlated with shorter duration.
MAUD duration showed an overall increase in recent years, except for 2024, indicating a slight improvement but minimal overall change.

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Implication

Observational cohort study examines factors influencing discontinuation of alcohol use disorder medications, highlighting implications for patient recovery.

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Cite This Study

Busch et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4d68101cf8926f0315d https://doi.org/10.1111/add.70498

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Discontinuation of medications for alcohol use disorder in the United States: Patient, prescriber and medication predictors

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Discontinuation of medications for alcohol use disorder in the United States: Patient, prescriber and medication predictors

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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