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June 12, 2026Obesity Science & PracticeOpen Access

AF-related mortality among US adults with obesity jumps ~11-fold between 1999 and 2024.

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Why the study?

AF is associated with increased mortality, particularly among individuals with obesity, but nationwide temporal trends in this population needed examination.

Population

63,853 AF- and obesity-related deaths among US adults aged ≥ 25 years

Comparison

Trends stratified by gender, race, and region

Design

Retrospective database analysis using CDC WONDER and Joinpoint regression

Key result

Between 1999 and 2024, age-adjusted atrial fibrillation-related mortality rates among US adults with obesity increased from 1.9 to 20.8 per 1,000,000 (AAPC 11.4; 95% CI 10.4-12.2).

Authors

AAAymen AhmedUniversity of MichiganRBRuqiat Masooma BatoolDow University of Health SciencesSWShoaib WaqasInternational Islamic University, Islamabad

Discussion

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Overview

Marked rise in AF mortality among obese adults warrants clinical awareness; hypothesis-generating for intervention trials.

Key Points

  • This research aims to analyze the trends in atrial fibrillation-related mortality among obese adults in the United States over 25 years.
  • Analyzed data from the CDC WONDER database for adults with obesity aged ≥ 25 years
  • Calculated age-adjusted mortality rates per 1,000,000 using Joinpoint regression
  • Stratified data by gender, race, and region
  • Identified a total of 63,853 AF-related deaths from 1999 to 2024
  • AF mortality rates increased from 1.9 in 1999 to 20.8 in 2024 (AAPC: 11.4 [95% CI: 10.4, 12.2])
  • Males had higher AAMRs than females, and White individuals exhibited higher AAMRs than Black individuals.

Study Design

Type

Observational (n=63,853)

Multicenter

Yes

Structured PICO

P
Population
63,853 deaths among adults aged ≥ 25 years with obesity and atrial fibrillation in the United States from 1999 to 2024.
O
Outcome
Age-adjusted mortality rates (AAMRs) per 1,000,000 for AF-related mortality and average annual percentage change (AAPC)hard clinical

Main Result

Effect estimate: AAPC 11.4 (95% CI 10.4-12.2)

Absolute Event Rate: 20.8% vs 1.9%

Atrial fibrillation-related mortality among adults with obesity in the US has significantly increased from 1999 to 2024, highlighting a growing public health concern.

Cite This Study

Ahmed et al. (2026) conducted an observational in Atrial fibrillation and obesity (n=63,853). Time period (1999 to 2024) vs. 1999 was evaluated on Age-adjusted AF-related mortality rate per 1,000,000 (AAPC 11.4, 95% CI 10.4-12.2). Between 1999 and 2024, age-adjusted atrial fibrillation-related mortality rates among US adults with obesity increased from 1.9 to 20.8 per 1,000,000 (AAPC 11.4; 95% CI 10.4-12.2).

synapsesocial.com/papers/6a2ba4d68101cf8926f0316bhttps://doi.org/10.1002/osp4.70160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Fri149: The Growing Burden: Atrial Fibrillation Mortality Trends Among Obese Adults in the United States (1999–2023)2025
  2. 2Abstract Fri091: Unraveling the Rising Tide: Trends and Disparities in Atrial Fibrillation Mortality in the United States, 1968–20232025
  3. 3National trends in mortality attributable to arrhythmias among adults with obesity in the United States, 1999–20202025 · 1 citations
  4. 4Obesity Subphenotypes in Atrial Fibrillation2026
  5. 5Mortality Trends in Atrial Fibrillation With Cardiomyopathy Among Patients Aged 25 and Older in the United States2025 · 2 citations