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June 12, 2026European Journal of Physical and Rehabilitation MedicineOpen Access

Clinical outcomes of rehabilitation with a robotic anthropomorphic exoskeleton in patients with motor-incomplete spinal cord injury: a multicenter randomized controlled trial

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Authors

CZCorrado ZenesiniIstituto delle Scienze Neurologiche di BolognaIBIlaria BaronciniUniversity of L'AquilaRPRoberto Di PalmaIstituti Clinici Scientifici Maugeri

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Overview

Randomized trial evaluates walking performance in patients with motor-incomplete spinal cord injury, suggesting limited additional benefit from robotic exoskeletons.

Key Points

  • The study aims to assess the effectiveness of a robotic exoskeleton as an add-on to conventional rehabilitation for improving walking performance in individuals with motor-incomplete spinal cord injury.
  • Multicenter randomized controlled trial.
  • Thirty-six patients with chronic motor-incomplete spinal cord injury were randomized to receive either exoskeleton-assisted training or standard rehabilitation.
  • Primary outcome measured was improvement in walking speed over 4 weeks.
  • At 4 weeks, 33.3% of the exoskeleton group and 46.7% of the control group improved walking speed (P=0.44).
  • At 8 weeks, improvement rates were 43.8% for the exoskeleton group and 66.7% for the control group (P=0.20).
  • No significant differences were observed between groups for gait endurance, muscle strength, or pain.

Cite This Study

Zenesini et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba4d68101cf8926f031eehttps://doi.org/10.23736/s1973-9087.26.09085-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of powered exoskeleton-assisted gait training in spinal cord injury: a randomized controlled pilot study2026
  2. 2Effectiveness of overground robotic exoskeletons in early inpatient rehabilitation for incomplete spinal cord injury: a systematic review protocol2026
  3. 3Personalized Exoskeleton Gait Training in Incomplete Spinal Cord Injury2025
  4. 4Exoskeleton-Assisted Gait Rehabilitation in Neurological Disorders: A Pilot Feasibility Study2026
  5. 5Effects of an exoskeleton robot on motor function in patients with spinal cord injuries: a systematic review and meta-analysis2025