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January 1, 2026Organic Chemistry Frontiers

Solvent Controlled Regioselective Iodocyclization of Propargylic Amides

Huilin Zhan Run Yu Shuxuan Liu Zhengyu Han Hai Huang

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Key Points

The aim is to develop controllable reactions for generating diverse products from propargylic amides.
Employ solvent-controlled techniques for iodocyclization.
Analyze product outcomes based on varying solvent conditions.
Utilize propargylic amides as a starting material.
Achieved multiple iodocyclization products with distinct regioselectivities.
Demonstrated solvent influence on reaction pathways and product distribution.

Implication

Demonstrates regioselective iodocyclization in amides, suggesting control over product variation.

Abstract

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Cite This Study

Zhan et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f032ef https://doi.org/10.1039/d6qo00517a

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