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June 12, 2026Scientific ReportsOpen Access

Reproductive toxicity of a nano-insecticide (chlorpyrifos) on male albino mice

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Authors

MAMarwa Abdeltawab AhmedFayoum UniversityAKAhmad Ali KandeelFayoum UniversityWTWessam Salim TawfikFayoum University

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Implication

Randomized trial evaluates reproductive toxicity of nano-insecticide in male mice, indicating risks to fertility.

Key Points

  • This study aims to assess the reproductive toxicity of chlorpyrifos nano-emulsion in male albino mice.
  • Male albino mice were divided into four groups (n=10) receiving different doses of CPF-NE via oral gavage for 35 days.
  • Various parameters were assessed, including gonadosomatic index, reproductive performance, and sperm parameters.
  • Histological examination of post-treatment testes was conducted.
  • Gonadosomatic index significantly decreased from 0.66 ± 0.02 to 0.31 ± 0.02 at high dose (p < 0.001).
  • Fertility index dropped to zero at high dose, indicating severe reproductive impairment.
  • Testosterone levels decreased from 4.2 ± 0.3 ng/mL to 1.8 ± 0.2 ng/mL (p < 0.001).

Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f0338bhttps://doi.org/10.1038/s41598-026-56438-0
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