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June 12, 2026Proceedings of the National Academy of SciencesOpen Access

Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread

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Authors

ASAnna SuchWOWeronika OrtmannGBGabriela Burczyk

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Overview

Randomized trial reveals that erythrocytes' ability to inhibit NET formation is lost in sepsis, suggesting new treatment paths.

Key Points

  • This research investigates how the loss of erythrocyte sialic acid affects neutrophil interactions and NET formation during sepsis.
  • Examined neutrophil and erythrocyte interactions in septic individuals and murine models.
  • Analyzed the role of sialic acid and Siglec molecules in neutrophil activation and NET inhibition.
  • Evaluated the effects of exogenous polysialic acid on neutrophil function post-sepsis.
  • Erythrocytes from septic individuals lose their ability to inhibit NET formation, confirmed by observed interactions.
  • Post-sepsis, interactions between erythrocytes and neutrophils were restored, demonstrating altered dynamics during inflammation.
  • Treatment with exogenous polysialic acid preserved erythrocyte's inhibitory function on NET formation.

Cite This Study

Such et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f03399https://doi.org/10.1073/pnas.2536989123
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