What question did this study set out to answer?

To investigate differences in biochemical markers and their correlation with bone densitometry scores in teenage patients with β-thalassemia major.

June 12, 2026Indian Journal of Physiology and Pharmacology

Assessment of some biochemical and bone turnover marker differences and their correlations with bone densitometry score in teenaged patients with β-thalassemia major in Basrah

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Authors

WAWasen Jameel Alzubaidi MAMustafa Abd Almajeed NINawal Khalil Ibrahim

Discussion

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Overview

Case–control study assesses biochemical differences and correlations with bone density in teenaged β-thalassemia major patients, suggesting imbalanced bone turnover.

Key Points

To investigate differences in biochemical markers and their correlation with bone densitometry scores in teenage patients with β-thalassemia major.
Case–control study conducted in 2023 with 90 subjects aged 12-15 years, including 45 with β-thalassemia major and 45 healthy controls.
Biochemical investigations and dual-energy X-ray absorptiometry scans were performed to evaluate bone mineral density and correlations with Z-scores.
Statistical analysis conducted using the Statistical Package for the Social Sciences version 29.
β-thalassemia major patients showed significantly lower body mass index, vitamin D3, and Z-scores, and higher levels of serum ferritin, PTH, and bone turnover markers.
Majority of β-thalassemia major cases exhibited osteopenia (51.1%) and osteoporosis (26.6%).
Non-significant negative correlations were observed between vitamin D3, serum ferritin, PTH, and osteocalcin with Z-score in cases.

Cite This Study

Alzubaidi et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f0344d https://doi.org/10.25259/ijpp_6_2025

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June 12, 2026Indian Journal of Physiology and Pharmacology

Assessment of some biochemical and bone turnover marker differences and their correlations with bone densitometry score in teenaged patients with β-thalassemia major in Basrah

View Full Paper

Ask AI

Bookmark

Authors

WAWasen Jameel Alzubaidi MAMustafa Abd Almajeed NINawal Khalil Ibrahim

Discussion

Member takes

Overview

Case–control study assesses biochemical differences and correlations with bone density in teenaged β-thalassemia major patients, suggesting imbalanced bone turnover.

Key Points

To investigate differences in biochemical markers and their correlation with bone densitometry scores in teenage patients with β-thalassemia major.
Case–control study conducted in 2023 with 90 subjects aged 12-15 years, including 45 with β-thalassemia major and 45 healthy controls.
Biochemical investigations and dual-energy X-ray absorptiometry scans were performed to evaluate bone mineral density and correlations with Z-scores.
Statistical analysis conducted using the Statistical Package for the Social Sciences version 29.
β-thalassemia major patients showed significantly lower body mass index, vitamin D3, and Z-scores, and higher levels of serum ferritin, PTH, and bone turnover markers.
Majority of β-thalassemia major cases exhibited osteopenia (51.1%) and osteoporosis (26.6%).
Non-significant negative correlations were observed between vitamin D3, serum ferritin, PTH, and osteocalcin with Z-score in cases.

Cite This Study

Alzubaidi et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba5068101cf8926f0344d https://doi.org/10.25259/ijpp_6_2025

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