Why the study?
Does GLP-1 administration alter metabolic substrate utilization in normal and ischemic rat hearts?
Population
Normal and ischemic rat hearts and isolated adult rat cardiomyocytes
Comparison
Glucagon-like peptide-1 (GLP-1) administration vs Untreated normal and ischemic rat…
Design
Preclinical
Follow-up
24 h reperfusion
Authors
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GLP-1 metabolic effects in ischemic rat hearts should not alter practice; leaves open translation to human cardioprotection.
Does GLP-1 administration alter metabolic substrate utilization in normal and ischemic rat hearts?
GLP-1 administration provides cardioprotection during ischemia-reperfusion injury by shifting metabolic substrate utilization toward more energy-efficient carbohydrate oxidation and anaerobic glycolysis.
Aravindhan et al. (2015) studied this question.
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