Key result
Surgical excision of atrial myxoma yields favorable recovery without further cerebral emboli in familial cavernomatosis.
Why the study?
Cardiac myxoma is an important cause of stroke in young adults, prompting a review of recent literature on its association with cardioembolic ischemic stroke alongside a relevant clinical case.
Case Report (n=1)
No
Atrial myxoma should be considered in the differential diagnosis of cardioembolic stroke in young adults, and surgical excision is an effective curative treatment.
Alerts clinicians to CM in young stroke patients; leaves open genetic interactions with cavernomatosis for validation.
Cardiac myxoma (CM) is the most common benign tumor of the heart and an important etiology of stroke in young adults. The study aimed to provide the latest literature data on CMs and, in particular, on the association between CM and cardioembolic ischemic stroke. It also discussed a specific instance of atrial myxoma (AM) in a young patient who suffered an ischemic stroke linked with familial cavernomatosis. The case presentation focuses on a 43-year-old woman showed up at the hospital's Emergency Room for transient speech disorders lasting about 15 minutes. The physical examination revealed preserved mental and cognitive status. Cranial magnetic resonance imaging (MRI) showed three areas of microvascular ischemia (frontal, parietal, and left occipital), in addition to multiple cavernomatous lesions. Because these microvascular ischemias were located in different vascular territories, we considered the cause to be embolic and completed the investigation with a transesophageal cardiac ultrasound that revealed a mobile and heterogeneous tumor mass in the left atrium. Histopathological investigation with immunohistochemistry proved the tumor to be a CM. The patient therapy included a multidisciplinary approach, which led to surgical excision of the tumor. The co-existence of cerebral cavernous malformations (CCMs) and AM might thus be coincidental or induced by a common genetic component. More cases are needed to verify or disprove the concept of a shared genetic basis for CCMs and myxoma.
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Botezat et al. (2025) conducted a case report in Atrial myxoma and ischemic stroke (n=1). Surgical excision was evaluated on Postoperative complications and cerebral emboli. Surgical excision of an atrial myxoma in a 43-year-old woman with ischemic stroke and familial cavernomatosis led to a favorable recovery without further cerebral emboli.
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