High-Throughput Profiling Of Anti-Viral And Self-Antigen Antibodies To Identify Etiology In Encephalitis (LS1.006)

David Acero-Garces; Moran Guo; Diana López; Martha Moyano; Laura Quintero; Maria Reyes; J M Carrobles Jimenez; Reydmar Lopez; Guillermo González-Manrique; Jairo Lizarazo Niño; Federico Silva; Angela Catalina Vallejo Cajigas; Viviana Martinez; Julie Benavides; Christian Rojas Cerón; J U A N P ROJAS; Gustavo Ramos; Jonathan Urrego; Susana Dominguez Penuela; Lyda Osorio; Benjamin Larman; Beatriz Parra; Carlos Pardo-Villamizar

doi:10.1212/wnl.0000000000217916

Key result

High-throughput profiling of viral and self-antigen antibodies maps the encephalitis reactome to improve diagnostic precision.

Why the study?

The study was conducted to characterize antibody reactivity against viruses and human peptides in patients with encephalitis to improve diagnostic precision.

Does high-throughput profiling of anti-viral and self-antigen antibodies improve diagnostic precision in patients with encephalitis?

Key Points

The aim is to enhance the diagnosis of encephalitis by evaluating antibody responses to viruses and human peptides.
High-throughput profiling of anti-viral and self-antigen antibodies
Characterization of reactivity against linear and conformational antigens
Focus on patients diagnosed with encephalitis
Identified significant antibody reactivities against specific viral antigens
Improved understanding of immunological responses in encephalitis patients
Enhanced diagnostic precision indicated by the profiling results

Structured PICO

Does high-throughput profiling of anti-viral and self-antigen antibodies improve diagnostic precision in patients with encephalitis?

P

Population

Patients with encephalitis

I

Intervention

High-throughput profiling of anti-viral and self-antigen antibodies

O

Outcome

Characterization of antibody reactivity (reactome) against viruses and human peptides to improve diagnostic precision

High-throughput antibody profiling aims to improve diagnostic precision in encephalitis.

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Implication

Antibody reactome profiling may aid encephalitis diagnosis; leaves open clinical utility pending validation studies.

Abstract

To characterize the antibody reactivity (reactome) against viruses and human peptides, including linear and conformational antigens, in patients with encephalitis, aiming to improve diagnostic precision.

Discussion

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Cite This Study

Acero-Garces et al. (2026) studied this question. High-throughput profiling of anti-viral and self-antigen antibodies aims to characterize the reactome in patients with encephalitis to improve diagnostic precision.

synapsesocial.com/papers/6a2bd1056550ea4541ffe7ce https://doi.org/10.1212/wnl.0000000000217916

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High-Throughput Profiling Of Anti-Viral And Self-Antigen Antibodies To Identify Etiology In Encephalitis (LS1.006)

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

High-Throughput Profiling Of Anti-Viral And Self-Antigen Antibodies To Identify Etiology In Encephalitis (LS1.006)

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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