Key result
Donanemab infusion is linked to acute encephalopathy and seizures with diagnostically challenging hyponatremia.
Why the study?
To describe a case of acute encephalopathy and seizure during donanemab infusion and highlight the diagnostic challenge of determining if hyponatremia stemmed from fluid overload or an infusion-related reaction.
Highlights a potential severe adverse event (encephalopathy, seizure, hyponatremia) associated with donanemab infusion and the diagnostic challenge of determining its etiology.
Answers are grounded in this paper and cite their sources.
Case report urges vigilance for encephalopathy during donanemab; leaves open hyponatremia mechanism and causality.
To describe a case of acute encephalopathy and seizure during donanemab infusion, highlighting the diagnostic challenge of determining whether hyponatremia resulted from fluid overload or an infusion-related reaction.
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Akhlaghipour et al. (2026) studied this question. Donanemab infusion was associated with acute encephalopathy and seizure, highlighting the diagnostic challenge of determining if hyponatremia resulted from fluid overload or an infusion reaction.
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