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June 12, 2026European Journal of Preventive CardiologyOpen Access

Heartfelt gains: quality of life in phase II cardiac rehabilitation

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Key result

Phase II CR linked to a ~2.6-point increase in SF-36 mental summary scores.

  • Δ +2.6 points
  • P=0.003
  • n=65

Why the study?

The study was conducted to evaluate the impact of a phase II cardiac rehabilitation program on health-related quality of life using validated questionnaires.

Does an exercise-based phase II cardiac rehabilitation program improve health-related quality of life in patients post-cardiovascular event?

Population

65 patients enrolled in an exercise-based phase II CR program

Design

Single-center prospective cohort study

Authors

IAI AraujoDFD FerreiraMVM Vilela

Discussion

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Overview

MSM gains may support mental health monitoring in cohorts; hypothesis-generating and requires randomized confirmation.

Key Points

  • To evaluate the effect of a phase II cardiac rehabilitation program on health-related quality of life (HRQOL).
  • Single center prospective cohort study
  • Participants completed validated questionnaires at baseline and follow-up
  • Analysis included physical and mental summary measures (PSM, MSM) from SF-36
  • Mental summary scores increased from 49.47 to 52.07 (Δ +2.6 points, p = 0.003)
  • Significant improvements in social functioning (+6.4 points, p = 0.002) and general health (+12.5 points, p = 0.007)
  • No significant changes in MacNew, Perceived Stress, or Minnesota scores.

Study Design

Type

Cohort (n=65)

Multicenter

No

Structured PICO

Does an exercise-based phase II cardiac rehabilitation program improve health-related quality of life in patients post-cardiovascular event?

P
Population
65 patients (mean age 61.3 years, 23.1% female) with multiple comorbidities including ischemic cardiomyopathy enrolled in an exercise-based phase II cardiac rehabilitation program.
E
Exposure
Exercise-based phase II cardiac rehabilitation (CR) program
O
Outcome
Health-related quality of life (HRQOL) assessed by SF-36 (including Physical and Mental Summary Measures), Macnew, Perceived stress, and Minnesota questionnaires at follow-uppatient reported

Main Result

Mean Difference: 2.6

Absolute Event Rate: 52.07% vs 49.47%

p-value: p=0.003

Phase II cardiac rehabilitation is associated with significant improvements in mental well-being and specific quality of life domains, though not all HRQOL instruments capture these changes.

Cite This Study

Araujo et al. (2026) conducted a cohort in Cardiovascular disease requiring cardiac rehabilitation (n=65). Phase II cardiac rehabilitation program vs. Baseline was evaluated on SF-36 mental summary measure (MSM) score (Δ +2.6 points, p=0.003). Phase II cardiac rehabilitation was associated with a significant increase in the SF-36 mental summary measure score from 49.47 to 52.07 (p=0.003).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe88bhttps://doi.org/10.1093/eurjpc/zwag249.358
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From surviving to thriving: long-term benefits of phase III cardiac rehabilitation2026
  2. 2Long-term exercise program in cardiovascular patients: the impact on quality of life2024
  3. 3Effects of Phase II Cardiac Rehabilitation on Job Stress and Health-Related Quality of Life After Return to Work in Middle-Aged Patients With Acute Myocardial Infarction2009 · 40 citations
  4. 4Quality of Life and Physical Ability Changes After Hospital-Based Cardiac Rehabilitation in Patients With Myocardial Infarction2017 · 23 citations
  5. 5Beyond phase 2: The impact of phase 3 cardiac rehabilitation on physical activity2024