Clinical and biochemical factors including prior ACEI/ARB use, type 2 diabetes, BUN, and serum albumin were independently associated with diuretic resistance, which occurred in 35.5% of patients.
Observational (n=76)
No
What is the frequency of and what factors are associated with diuretic resistance in patients hospitalized with decompensated heart failure?
Diuretic resistance is common (35.5%) in patients hospitalized with decompensated heart failure and is independently associated with prior ACEI/ARB use, diabetes, BUN, and albumin levels.
Background/Objectives: Diuretic resistance is a recognized complication in patients with heart failure (HF) and is associated with worse clinical outcomes; however, information regarding its frequency and associated factors in hospitalized patients in Mexico is limited. This study aimed to describe the frequency of diuretic resistance in patients hospitalized with HF in a hospital unit in western Mexico and to identify factors associated with diuretic resistance. Methods: This retrospective study used data obtained from clinical records. Patients older than 18 years with decompensated HF whose complete clinical records included the variables of interest were included. Patients were classified according to the presence or absence of diuretic resistance. Bivariate and multivariate analyses were performed to evaluate factors associated with diuretic resistance. Results: A total of 76 patients were analyzed, and the frequency of diuretic resistance was 35.5% (n = 27). In bivariate analysis, type 2 diabetes mellitus, chronic kidney disease, elevated creatinine, urea, blood urea nitrogen (BUN), and urine protein levels, decreased glomerular filtration rate (GFR) and serum albumin, and prior treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and angiotensin-converting enzyme inhibitors/angiotensin II receptor antagonists (ACEI/AARII) were significantly associated with diuretic resistance. In the multivariate logistic regression model, prior ACEI/AARII treatment, history of type 2 diabetes mellitus, BUN levels, and serum albumin levels remained independently associated with diuretic resistance classification. Conclusions: Diuretic resistance was frequent in this cohort of patients hospitalized with decompensated heart failure, and several clinical and biochemical factors were independently associated with its occurrence. These findings may help identify patients at higher risk of diuretic resistance, although they should be confirmed in future prospective studies.
Torre-Cabrales et al. (Thu,) conducted a observational in Decompensated heart failure (n=76). Clinical and biochemical risk factors was evaluated on Diuretic resistance. Clinical and biochemical factors including prior ACEI/ARB use, type 2 diabetes, BUN, and serum albumin were independently associated with diuretic resistance, which occurred in 35.5% of patients.
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