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June 12, 2026European Journal of Preventive CardiologyOpen Access

Comparison of different aerobic exercise modalities on echocardiographic variables in early cardiac rehabilitation

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Key result

Short-HIIT drives greater LV volumetric remodeling than MICT during cardiac rehabilitation.

  • P=0.039
  • n=24

Why the study?

The differential impact of high-intensity interval training versus moderate-intensity continuous training on echocardiographic parameters, cardiac structure, and remodelling had not been compared during early cardiac rehabilitation.

Do different aerobic exercise modalities (short-HIIT, long-HIIT, MICT) improve echocardiographic variables in patients with stable CAD in early cardiac rehabilitation?

Population

24 patients with stable CAD enrolled in phase II CR

Comparison

Short-HIIT vs long-HIIT vs MICT

Design

Randomised trial

Follow-up

6 weeks

Authors

LKL Fuertes KenneallyARA M R Agustin Manresa RocamoraLBL S B Laura Sarrion Brotons

Discussion

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Overview

Exercise modality may differentially affect ventricular remodeling in early CAD rehab; leaves open optimal protocol selection.

Key Points

  • To compare the effects of short-HIIT, long-HIIT, and MICT on echocardiographic variables in early cardiac rehabilitation.
  • 24 patients with stable CAD were randomized to short-HIIT, long-HIIT, or MICT.
  • Echocardiography was performed at baseline and after 6 weeks.
  • Mixed ANOVA models assessed time and time×group effects on echocardiographic variables.
  • LVEDV increased significantly for short-HIIT (p=0.038) and showed group interaction (p=0.039).
  • LVEDD increased only in MICT (interaction p=0.012).
  • TAPSE increased (p=0.030), and sPAP decreased markedly (p=0.001), indicating improved RV systolic performance.

Study Design

Type

RCT (n=24)

Structured PICO

Do different aerobic exercise modalities (short-HIIT, long-HIIT, MICT) improve echocardiographic variables in patients with stable CAD in early cardiac rehabilitation?

P
Population
24 patients with stable coronary artery disease enrolled in phase II cardiac rehabilitation, followed for 6 weeks.
I
Intervention
Short high-intensity interval training (short-HIIT) or long high-intensity interval training (long-HIIT) for 6 weeks
C
Comparator
Moderate-intensity continuous training (MICT) for 6 weeks
O
Outcome
Echocardiographic variables including left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), left and right ventricular end-diastolic diameter (LVEDD, RVEDD), left atrial volume indexed (LAVi), mitral annular tissue Doppler velocity (e'), E/e' ratio, tricuspid annular plane systolic excursion (TAPSE), LV ejection fraction (LVEF), and systolic pulmonary artery pressure (sPAP) at 6 weekssurrogate

Main Result

p-value: p=0.039

Six weeks of cardiac rehabilitation drives rapid structural cardiac changes, with short-HIIT producing the most pronounced left ventricular volumetric remodeling compared to MICT.

Cite This Study

Kenneally et al. (2026) conducted an RCT in Stable coronary artery disease (CAD) (n=24). Short-HIIT and long-HIIT vs. Moderate-intensity continuous training (MICT) was evaluated on Left- and right-heart structure and function (echocardiographic parameters) (p=0.039). Short-HIIT produced more pronounced left ventricular volumetric remodelling than MICT (LVEDV time×group p=0.039), while cardiac rehabilitation improved right ventricular systolic function (p=0.030).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe89ehttps://doi.org/10.1093/eurjpc/zwag249.160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short- and Long-Term Effects of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Left Ventricular Remodeling in Patients Early After ST-Segment Elevation Myocardial Infarction—The HIIT-EARLY Randomized Controlled Trial2022 · 21 citations
  2. 2Time-Course of Physiological Adaptations to High-Intensity Interval Training-Based Cardiac Rehabilitation After Myocardial Infarction2026
  3. 3A comprehensive analysis of the impact of high-intensity interval vs. moderate-intensity continuous training on global and regional myocardial function in patients early after acute myocardial infarction: the STRAICT randomized controlled trial2025 · 4 citations
  4. 4Comparing high-intensity versus moderate-intensity exercise training in coronary artery disease patients: a randomized controlled trial with 6- and 12-month follow-up2024 · 6 citations
  5. 5Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Body Composition and Blood Biomarkers in Coronary Artery Disease Patients: A Randomized Controlled Trial2024 · 11 citations