Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 12, 2026European Journal of Preventive CardiologyOpen Access

Better compliance to a personalized physical activity program optimizes physical fitness in HFpEF: a sub-analysis from the PRIORITY study

View Full Paper
Ask AI
Bookmark
Share

Key result

High exercise compliance in HFpEF improves HR at VAT by ~9 bpm vs low compliance.

  • P=0.0005
  • n=107

Why the study?

Physical activity improves outcomes in HFpEF, but uptake and compliance remain limited. This sub-analysis evaluated whether compliance differences to a hybrid exercise and physical activity intervention affected physical fitness improvements at 4 months.

Does higher compliance to a personalized physical activity program improve physical fitness in patients with HFpEF?

Population

107 HFpEF patients randomized to intervention in the PRIORITY trial

Comparison

High compliance vs low compliance to a hybrid exercise program

Design

Sub-analysis of a randomized trial

Follow-up

4 months

Authors

DFD FilosAristotle University of ThessalonikiJCJ ClaesKU LeuvenYBY BekhuisKU Leuven

Discussion

Loading...

Member takes

Implication

Target adherence to maximize hybrid exercise benefits in HFpEF; extends RCT evidence linking compliance to fitness gains.

Key Points

  • This analysis examines how compliance with a hybrid exercise program influences physical fitness in HFpEF patients.
  • 156 HFpEF patients randomized to a hybrid intervention with 10 supervised and home-based sessions.
  • Compliance assessed using weekly TRIMP and spectral clustering to identify high and low compliance groups.
  • Physical fitness measured at baseline and after 4 months using cardiopulmonary exercise test.
  • Identified 49 highly compliant and 58 low compliant patients, with significant differences in HR@VAT (p < 0.0001).
  • Highly compliant patients improved HR@VAT (3.7±9.9 bpm) while low compliant patients decreased (-5.35±16.7 bpm, p = 0.0005).
  • Mixed-effects models confirmed significant interactions for VO2VAT, workload, and HR@VAT across compliance clusters over time.

Study Design

Type

RCT (n=107)

Randomization

randomized

Structured PICO

Does higher compliance to a personalized physical activity program improve physical fitness in patients with HFpEF?

P
Population
107 patients with HFpEF randomized to a hybrid exercise intervention, followed for 4 months to assess the impact of compliance on physical fitness.
I
Intervention
High compliance (mean TRIMP 403) to a hybrid exercise and physical activity intervention combining 10 supervised sessions with a home-based remotely monitored physical activity programme over 4 months
C
Comparator
Low compliance (mean TRIMP 73) to the same hybrid exercise and physical activity intervention
O
Outcome
Changes in physical fitness parameters (HR@VAT, VO2VAT, workload at VAT) at 4 months measured by cardiopulmonary exercise testsurrogate

Main Result

Absolute Event Rate: 3.7% vs -5.35%

p-value: p=0.0005

Higher compliance to a hybrid supervised and home-based exercise program in HFpEF patients is associated with greater short-term improvements in submaximal physical fitness parameters.

Limitations

  • Longer follow-up is needed to determine the long-term impact of compliance on HFpEF outcomes.
  • Short follow-up duration

Cite This Study

Filos et al. (2026) conducted an RCT in Heart failure with preserved ejection fraction (HFpEF) (n=107). High compliance to a hybrid exercise and physical activity intervention vs. Low compliance was evaluated on Change in heart rate at ventilatory anaerobic threshold (HR@VAT) at 4 months (p=0.0005). High compliance to a hybrid exercise program in HFpEF patients significantly improved heart rate at ventilatory anaerobic threshold compared to low compliance (3.7 vs -5.35 bpm; P=0.0005).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe926https://doi.org/10.1093/eurjpc/zwag249.046

Topics

Cardiac Rehabilitation and Lifestyle Interventions
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1‘Huffing and puffing’ back to health: learning about adherence to exercise training in heart failure with preserved ejection fraction2024 · 1 citations
  2. 2Patient-centered wearable-integrated rehabilitation program for patients with heart failure: a multicenter randomized controlled trial2026
  3. 3Cardiovascular effects of preferred HOMe-based EXercise training and extended adherence measures in systolic heart failure2025
  4. 4Home-based physical activity intervention (Active-at-Home-HF) improves left atrial function, exercise duration and quality of life in heart failure with preserved ejection fraction2024
  5. 5Adherence to long-term telemonitoring-supported physical activity in patients with chronic heart failure2024 · 11 citations