Key result
MECKI score demonstrates high short-term reproducibility in ambulatory HFrEF patients.
Why the study?
Understanding the short-term variability of the MECKI score was needed to distinguish random fluctuations from clinically meaningful changes and define thresholds separating biological variability from true clinical change in HFrEF.
Does the MECKI score demonstrate short-term reproducibility in ambulatory patients with HFrEF?
Population
404 HFrEF patients (LVEF <40%) across four Italian HF centers
Comparison
Two CPETs with laboratory and echocardiographic data repeated approximately one week apart
Design
Prospective multicenter cohort study
Follow-up
Approximately one week
Authors
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Low MECKI variability over 1 week supports serial monitoring in HFrEF; leaves open validation of change thresholds.
Observational (n=404)
Yes
Does the MECKI score demonstrate short-term reproducibility in ambulatory patients with HFrEF?
Mean Difference: -0.004 (95% CI -0.042–0.034)
The MECKI score demonstrates high short-term reproducibility in ambulatory HFrEF patients, supporting its reliability as a stable prognostic tool in clinical practice.
Vignati et al. (2026) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=404). MECKI score assessment was evaluated on Short-term variability of the MECKI score (mean difference -0.004, 95% CI -0.042 to 0.034). The MECKI score demonstrated high short-term reproducibility in ambulatory HFrEF patients, with a mean difference of -0.004 and limits of agreement from -0.042 to 0.034 between tests one week apart.
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