Key result
MECKI score shows high short-term reproducibility in HFrEF patients tested one week apart.
Why the study?
Cardiopulmonary exercise testing variables have reproducibility challenges, making understanding the short-term variability of the MECKI score crucial to distinguish random fluctuations from clinically meaningful changes.
Population
404 HFrEF patients with LVEF <40% across four Italian HF centers
Comparison
Two CPETs and evaluations approximately one week apart
Design
Prospective multicenter cohort study
Follow-up
Approximately one week
Authors
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Supports MECKI score reliability for serial HFrEF monitoring; leaves open validation of change thresholds in prospective outcome studies.
Observational (n=404)
Yes
Mean Difference: -0.004 (95% CI -0.042–0.034)
The MECKI score demonstrates high short-term reproducibility in ambulatory HFrEF patients, supporting its reliability as a stable prognostic tool.
Mapelli et al. (2026) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=404). MECKI score assessment was evaluated on Short-term variability of MECKI score values (MD -0.004, 95% CI -0.042 to 0.034). The MECKI score demonstrated high short-term reproducibility in HFrEF patients, with a mean difference of -0.004 and limits of agreement from -0.042 to 0.034 between tests one week apart.
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