An intrinsic capacity deficit score of 4+ in individuals with diabetes significantly increased the risk of CVD, particularly PAD (HR 3.25, 95% CI 2.44-4.33), compared to a score of 0.
Does a higher intrinsic capacity deficit score increase the risk of incident cardiovascular disease in individuals with diabetes?
A higher intrinsic capacity deficit score is associated with an increased risk of incident cardiovascular diseases in individuals with diabetes, independent of genetic susceptibility.
Absolute Event Rate: 0% vs 0%
BACKGROUND: The relationship between intrinsic capacity (IC), genetic susceptibility, and CVD outcomes in individuals with diabetes remains unclear. METHODS: Data were obtained from 18 333 participants with diabetes (58.63 ± 7.54 years). The IC deficit score was categorised into five levels: 0, 1, 2, 3, and 4+. Outcomes included: hypertension, IHD, stroke, PAD, HF, and AF. Genetic risk scores (PRS) were constructed based on previously identified single nucleotide polymorphisms (SNPs) associated with these outcomes. RESULTS: Over a follow-up period of 9.91 to 13.43 years. Compared to those with an IC deficit score of 0, diabetes participants with a score of 4+ had significantly elevated risks, particularly for PAD (HR: 3.25, 95% CI: 2.44-4.33). The association between IC deficit score and IHD risk was stronger in individuals with low genetic risk. Notably, even among those with high genetic risk, an IC deficit score of 0 was linked to a lower risk of CVD outcomes. CONCLUSIONS: In individuals with diabetes, a higher IC deficit score is associated with an increased risk of hypertension, ischemic heart disease, stroke, PAD, HF, and AF.
Chen et al. (Wed,) reported a other. An intrinsic capacity deficit score of 4+ in individuals with diabetes significantly increased the risk of CVD, particularly PAD (HR 3.25, 95% CI 2.44-4.33), compared to a score of 0.