August 29, 2007New England Journal of Medicine664 citations
View Full PaperMechanisms of Anabolic Therapies for Osteoporosis
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Abstract
Antiresorptive agents help to restore skeletal balance by reducing bone turnover, primarily at the tissue level. Another therapeutic approach is to enhance bone formation with the use of anabolic agents, which differ fundamentally from antiresorptive drugs in their primary mechanism of action. This article reviews the mechanisms of polypeptide anabolic agents and strontium as potential therapeutic options for osteoporosis.
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