Key result
Takotsubo syndrome is linked to marked systemic metabolic alterations, including elevated ketone bodies and glutamate.
Why the study?
Systemic biochemical evidence of augmented oxidant activity in patients with Takotsubo syndrome was lacking.
Does Takotsubo syndrome present with specific systemic metabolic profile alterations compared to healthy controls?
Case-Control (n=20)
No
Does Takotsubo syndrome present with specific systemic metabolic profile alterations compared to healthy controls?
The identification of a distinct metabolic signature in Takotsubo syndrome highlights a systemic response to oxidative stress and suggests potential novel biomarkers for evaluating disease severity.
Metabolic signature in Takotsubo syndrome may reflect oxidative stress; hypothesis-generating for biomarkers and requires prospective validation.
Takotsubo syndrome (TTS) presents as an acute coronary syndrome characterized by severe left ventricular (LV) dysfunction and non-obstructive coronary artery disease that typically shows spontaneous recovery within days or weeks. The mechanisms behind TTS are mainly related to beta-adrenergic overstimulation and acute endogenous catecholamine surge, both of which could increase oxidative status that may induce further deterioration of cardiac function. Although several studies reported evidence of inflammation and oxidative stress overload in myocardial tissue of TTS models, systemic biochemical evidence of augmented oxidant activity in patients with TTS is lacking. In this study, serum samples of ten TTS patients and ten controls have been analyzed using 1H-NMR spectroscopy. The results of this pilot study show a marked alteration in the systemic metabolic profile of TTS patients, mainly characterized by significant elevation of ketone bodies, 2-hydroxybutyrate, acetyl-L-carnitine, and glutamate levels, in contrast with a decrease of several amino acid levels. The overall metabolic fingerprint reflects a systemic response to oxidative stress caused by the stressor that triggered the syndrome’s onset.
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Vanni et al. (2021) conducted a case-control in Takotsubo syndrome (n=20). Takotsubo syndrome vs. Age- and sex-matched controls was evaluated on Systemic serum metabolic profile alterations measured by 1H-NMR spectroscopy. Takotsubo syndrome was associated with marked systemic metabolic alterations, including significant elevations in ketone bodies, 2-hydroxybutyrate, acetyl-L-carnitine, and glutamate, and decreased amino acid levels.
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