Key result
Three weeks of physical training significantly decreased HOMA IR from 3.7 to 2.3 (p<0.05) in chronic heart failure patients with baseline insulin resistance.
Why the study?
Does physical training improve insulin resistance in patients with chronic heart failure?
Observational (n=20)
Open-label
No
Does physical training improve insulin resistance in patients with chronic heart failure?
Short-term physical training improves hyperinsulinemia and insulin resistance in patients with chronic heart failure who have baseline insulin resistance.
May support short-term training in insulin-resistant HF; leaves open need for RCTs before practice change.
BACKGROUND: The effect of physical training on insulin resistance (IR) in chronic heart failure (CHF) remains unclear. METHODS AND RESULTS: Fourteen patients with CHF performed physical training using a bicycle ergometer; 9 patients (64%) were hyperinsulinemic and insulin resistant (HOMA IR > 1.97). Exercise tolerance increased (5.1 +/- 1.7 to 6.9 +/- 2.7 METs, p < 0.05) and heart rate at rest decreased (82 +/- 15 to 72 +/- 6, p < 0.05) in the IR group after physical training. Physical training also decreased the insulin level (15.1 +/- 5.6 to 9.8 +/- 2.6 microU/ml, p < 0.05) and HOMA IR (3.7 +/- 1.4 to 2.3 +/- 0.6, p < 0.05) in the IR group, but not in the 5 patients (36%) without IR or in 6 control patients. CONCLUSION: Physical training can improve hyperinsulinemia and IR in patients with CHF.
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Nishiyama et al. (2006) conducted an observational in Chronic Heart Failure (n=20). Physical training (bicycle ergometer) vs. Control group (conventional drug therapy) was evaluated on Homeostasis model assessment insulin resistance (HOMA IR) (p=<0.05). Three weeks of physical training significantly decreased HOMA IR from 3.7 to 2.3 (p<0.05) in chronic heart failure patients with baseline insulin resistance.
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