Key result
Arterial shear stress decreases endothelial cell apoptosis and increases VEGF expression via KLF2 induction and VEGFR2 activation, promoting vascular endothelial cell survival.
Arterial shear stress promotes endothelial cell survival through a VEGF-VEGFR2 autocrine-juxtacrine signaling mechanism.
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Requires human artery validation before therapeutic consideration; extends shear stress-VEGF mechanisms in animal models.
Paz et al. (2012) studied Endothelial cell survival. Arterial shear stress vs. Static conditions was evaluated on VEGF expression and endothelial cell apoptosis. Arterial shear stress decreases endothelial cell apoptosis and increases VEGF expression via KLF2 induction and VEGFR2 activation, promoting vascular endothelial cell survival.
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