Key result
Six weeks of single-leg knee extensor exercise training significantly improved arm flow-mediated dilation from 1% to 5% in older subjects, indicating preserved vascular plasticity with age.
Why the study?
Does 6 weeks of single-leg knee extensor exercise training improve flow-mediated vasodilation in older subjects?
Population
11 subjects including 5 young (22 +/- 1 yr old) and 6 old (71 +/- 2 yr old) subjects
Comparison
6 weeks of single-leg knee extensor exercise… vs Baseline measurements and young subjects
Design
Cohort
Follow-up
6 weeks
Authors
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May improve remote endothelial function after leg training in older adults; hypothesis-generating for systemic plasticity and requires larger randomized confirmation.
Does 6 weeks of single-leg knee extensor exercise training improve flow-mediated vasodilation in older subjects?
Absolute Event Rate: 5% vs 1%
Exercise training improves arm vasodilation in older subjects, demonstrating preserved vascular plasticity with age and challenging the convention of universally diminished endothelial function.
Wray et al. (2005) studied this question. Single-leg knee extensor exercise training vs. Baseline was evaluated on Arm flow-mediated dilation (FMD). Six weeks of single-leg knee extensor exercise training significantly improved arm flow-mediated dilation from 1% to 5% in older subjects, indicating preserved vascular plasticity with age.
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